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. 2012 May 23;142(7):1280–1285. doi: 10.3945/jn.111.153056

FIGURE 1.

FIGURE 1

Decrease in plasma PLP with higher IS at each level of vitamin B-6 intake in 1863 participants of the seventh examination of the Framingham Offspring Study. The IS is the sum of Z-scores of CRP, fibrinogen, IL-6, TNFα, TNFR-2, osteoprotegerin, P-selectin, CD40L, ICAM-1, MCP-1, myeloperoxidase, LPLP-A2 mass, LPLP-A2 activity, and isoprostanes. Geometric means (95%CI) of plasma PLP (nmol/L) from participants of the seventh examination (n = 1863) adjusted for sex, age, BMI, plasma homocysteine, folate, vitamin B-12, creatinine, total cholesterol, protein intake, energy intake, NSAID use, and cigarette use. P-trend for the relation between plasma PLP and IS stratified by vitamin B-6 intake was derived by entering IS into the model as a continuous rather than categorical variable. n = 631 for vitamin B-6 intake >4.2 mg/d, n = 610 for vitamin B-6 intake between 2.2 and 4.2 mg/d, and n = 622 for vitamin B-6 intake <2.2 mg/d. CD40L, CD40 ligand; ICAM-1, intracellular adhesion molecule-1; IS, inflammation score; LPLP-A2, lipoprotein phospholipase A2; MCP-1, monocyte chemoattractant protein-1; NSAID, nonsteroidal antiinflammatory drug; PLP, pyridoxal-5-phosphate; TNFR-2, TNF receptor-2.