TABLE 2.
Associations between PLP concentration and inflammation indices in participants of the Framingham Offspring Study seventh examination1
| Plasma PLP, nmol/L |
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| Tertile category of inflammation index |
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| Inflammation index | 1 | 2 | 3 | P-trend2 |
| IS3 | 80 (74, 86) | 71 (67, 76) | 61 (57, 65) | <0.001 |
| n | 621 | 621 | 621 | |
| IS-acute phase reactants3 | 76 (71, 80) | 68 (64, 72) | 61 (58, 65) | <0.001 |
| n | 605 | 641 | 617 | |
| IS-cytokines3 | 76 (71, 81) | 71 (67, 76) | 61 (57, 65) | <0.001 |
| n | 621 | 621 | 621 | |
| IS-oxidative stress3 | 73 (69, 78) | 70 (66, 75) | 63 (59, 66) | <0.001 |
| n | 743 | 743 | 743 | |
| IS-selectins3 | 69 (65, 74) | 69 (65, 73) | 66 (62, 70) | 0.08 |
| n | 743 | 743 | 743 | |
| ICAM-13 | 72 (68, 77) | 70 (66, 74) | 64 (61, 69) | <0.001 |
| n | 743 | 743 | 743 | |
| MCP-13 | 66 (62, 70) | 70 (66, 74) | 67 (63, 71) | 0.50 |
| n | 743 | 743 | 743 | |
Values are geometric mean (95% CI) from participants with valid dietary intake data who were not missing data on inflammatory biomarkers or other covariates stratified by tertile category of inflammation indices and adjusted for sex, age, BMI, circulating homocysteine, folate, vitamin B-12, creatinine, and total cholesterol, vitamin B-6, protein, and energy intakes, and NSAID, cigarette, and multivitamin use. CD40L, CD40 ligand; ICAM-1, intracellular adhesion molecule-1; IS, inflammation score; LPLP-A2, lipoprotein phospholipase A2; NSAID, nonsteroidal antiinflammatory drug; PLP, pyridoxal-5-phosphate; TNFR-2, TNF receptor-2.
value of the regression coefficient for the independent variable (i.e., IS or biomarker) derived by entering this variable into the model as a continuous variable.
Summed Z-scores of: CRP, fibrinogen, IL-6, TNFα, TNFR-2,osteoprotegerin, P-selectin, CD40L, ICAM-1, MCP-1, myeloperoxidase, LPLP-A2 mass, LPLP-A2 activity, and isoprostanes; IS- acute phase reactants = summed Z-scores of: CRP and fibrinogen, IS- Cytokines = summed Z-scores of: IL-6, TNFα, TNFR-2, and osteoprotegerin, IS-oxidative stress = summed Z-scores of: myeloperoxidase, LPLP-A2 mass, LPLP- A2 activity, and isoprostanes, IS-Selectins = summed Z-scores of: P-selectin and CD40L.