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. 2012 Jun 15;23(12):2388–2398. doi: 10.1091/mbc.E12-03-0209

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© 2012 Sun et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — PP2A-deficient mutants confer myriocin resistance specifically through effects on the Orm proteins. (a, b, d) Impaired Cdc55-PP2A activity results in myriocin resistance dependent on Orm phosphorylation status. Various mutants were grown at 30°C for 3 d on plates containing the indicated myriocin concentrations. (c) Orm proteins are required for myriocin resistance but not rapamycin resistance in cdc55∆. Various mutants were grown on plates containing 0.5 μg/ml myriocin or 100 nM rapamycin at 30°C for 3 d.