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. 2012 Jun 13;7(6):e38853. doi: 10.1371/journal.pone.0038853

Figure 2. ART is highly efficient in disseminated high-titer HIV infection in hu mice.

Figure 2

(A) Response to ART with AZT, 3TC and RTV, followed by 3TC, TDF and TMC278-LA. Note that the initial regimen was poorly tolerated by the hu mice that resulted in reduced food uptake and thus a somewhat lower response rate. (B) Mock-treated HIV-infected mice (n = 8). (C and D) Mice with suppressed HIV RNA were either kept on ART (n = 11) (C) or switched to monotherapy with TMC278-LA alone (n = 10) (D). ART and monotherapy were interrupted to monitor the mice for viral rebound. We included two mice with viral failure into the group treated with TMC-278-LA alone. ┼ indicates that one mouse died within one week of bleeding. (E and F) Weight monitoring of mice either constantly on combined ART (E) or switched subsequently to monotherapy with TMC278-LA (F). Compilation of weight loss over time of all mice, i.e., mice on ART with viral failure (VF), mice on ART with suppressed HIV RNA and untreated HIV-infected mice (controls) (G). Grey-spotted area indicates the time period hu mice were on ART with AZT, 3TC and RTV, grey-plain shaded the time period on ART with 3TC, TDF and TMC278-LA. The coloured circles indicate the mice with viral failure.