Table 1. Emergence of resistance in the mice under monotherapy with TMC278-LA.

Mouse (Identifier)	day 30 (baseline)	day 73 (under ART with 3TC, TDF, TMC278-LA)	day 128 (38 days under TMC278-LA alone)	day 150 (22 days after interruption of TMC278-LA)
# 192**	S*	n.d.¶	S	S
# 242	S	n.d.	n.d.	S
# 232	S	n.d.	E138K	E138K
# 190***	S	M184V	n.d.	M184I/E138K
# 189	S	S	M184I/K101E/E138K	M184I/K101E/E138K
# 191***	S	M184I	M184I/E138K	M184I/E138K
# 224***	S	M184I	n.d.	M184I/E138K

^*S = susceptible (wildtype strain).

^**#192 showed suppressed HIV RNA under TMC278-LA monotherapy.

^***#191, 224 showed viral failure under the ART regimen of 3TC, TDF and TMC278-LA. #190 gave a positive signal for HIV RNA but below the limit of detection (<800 copies/ml)

#221, 245 only baseline analyses have been done, and therefore data from these mice were not integrated in the table.

¶#n.d. = not done.