Figure 5. Reduction of GSH by BSO alters TGV potency and NS5B double band formation.

A) EC₅₀s of TGV and VX-222 in 1b replicon cells co-treated with BSO. Replicon cells were pretreated for 24 hours with 5 mM BSO to reduce GSH prior to compound addition. B) NS5B Western blot of lysates from full-length NS5B overexpressing Lunet cells treated varying concentrations of BSO added together with 10 µM TGV.