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. 2012 Jun 13;7(6):e38894. doi: 10.1371/journal.pone.0038894

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Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Mice with genotypes of Cre/RBP-J^f/+, 3B4/Cre/RBP-J^f/+, Cre/RBP-J^f/f and 3B4/Cre/RBP-J^f/f were compared. Deletion of the floxed RBP-J exons was induced through the injection of poly(I:C); mice were then sacrificed and subjected to MZ and FO B cell analysis by FCM. The cells were first gated by anti-CD19 and then CD21 and CD23 expression was utilized to discriminate between FO (CD19⁺CD21^intCD23^hi) and MZ B (CD19⁺CD21^hiCD23^lo) cells. The numbers denote the percentages of cells in the indicated squares. Data are representative of five independent experiments.