Figure 7. A model for chromosomal DNA organization suggested by hexagonal crystal packing.

(A) The N-terminal Lsr2 dimerization domain in the P3₁21 space group in two orientations; (B) Proposed orientation of DNA (in blue) between N-terminal chains and a 90° rotation illustrating this from above. The C-terminal DNA-binding domains (in orange) have been positioned according to Gordon et al. [22]; (C) Our model of full-length Lsr2 binding to DNA and forming chains cross-linking multiple strands of DNA. The dimension at the bottom of the figure is consistent with the compact fibrils seen in Figure 6B.