Table 1. Optimal performance on 3681 human locative protein dataset.

Subcellular location	Size	MLMK-TLM-I (optimistic)			MLMK-TLM-II (moderate)			MLMK-TLM-III (pessimistic)
		SP	SE	MCC	SP	SE	MCC	SP	SE	MCC
Centrosome	77	0.9063	0.7532	0.8229	0.8772	0.6494	0.7504	0.8235	0.7273	0.7694
Cytoplasm	817	0.7845	0.8556	0.7704	0.8061	0.8042	0.7552	0.7380	0.8446	0.7322
Cytoskeleton	79	0.9123	0.6582	0.7710	0.7910	0.6709	0.7231	0.8333	0.6329	0.7212
Endosome	24	0.9167	0.4583	0.6467	0.8000	0.5000	0.6306	0.9167	0.4583	0.6467
Endoplasmic reticulum	229	0.9302	0.8734	0.8951	0.9151	0.8472	0.8730	0.8818	0.8472	0.8557
Extracell	385	0.9525	0.8857	0.9096	0.9284	0.8753	0.8906	0.9413	0.8753	0.8977
Golgi apparatus	161	0.9214	0.8012	0.8534	0.9161	0.8137	0.8576	0.8705	0.7516	0.8010
Lysosome	77	1.0000	0.7143	0.8426	0.9828	0.7403	0.8504	0.9825	0.7273	0.8426
Microsome	24	0.9500	0.7917	0.8665	0.8947	0.7083	0.7949	0.8947	0.7083	0.7949
Mitochondrion	364	0.9620	0.9038	0.9255	0.9477	0.8956	0.9131	0.9339	0.8544	0.8825
Nucleus	1021	0.8479	0.9334	0.8486	0.8156	0.9314	0.8238	0.8287	0.8815	0.8028
Peroxisome	47	0.9750	0.8298	0.8983	0.9318	0.8723	0.9004	0.9762	0.8723	0.9219
Plasma membrane	354	0.8746	0.8672	0.8576	0.8169	0.8446	0.8130	0.8680	0.8362	0.8370
Synapse	22	1.0000	0.5455	0.7375	1.0000	0.5455	0.7375	1.0000	0.5000	0.7060
Overall Accuracy/MCC		87.04%/0.8606			85.22%/0.8411			83.97%/0.8277