. 2012 Jun 13;7(6):e37716. doi: 10.1371/journal.pone.0037716

Table 6. Multi-labelling evaluation—non-perfect label match.

		True Subcellular Locations	Predicted Subcellular Locations
*Optimistic Case* *[> = 0.09]*	*O43663*	*Cytoplasm; Nucleus*	*Nucleus[0.471]; Cytoplasm[0.365]; Cytoskeleton[0.136]*
	*Q92797*	*Cytoskeleton; Nucleus*	*Nucleus[0.470]; Cytoplasm[0.257]; Plasma membrane[0.129]*
	*Q92597*	*Cytoplasm; Nucleus; Plasma membrane*	*Nucleus[0.588]; Cytoplasm[0.333]*
	*P30533*	*Cytoplasm; Endoplasmic reticulum*	*Endoplasmic reticulum[0.237]; Cytoplasm[0.229]* *Nucleus[0.115]; Plasma membrane[0.181]*
	*Q9HD36*	*Mitochondrion; Nucleus*	*Nucleus[0.562];Mitochondrion[0.160];Cytoplasm[0.156]*
	*P22059*	*Cytoplasm; Golgi apparatus*	*Golgi apparatus[0.837]*
	*Q86YR5*	*Endoplasmic reticulum; Golgi apparatus*	*Golgi apparatus[0.454]; Endoplasmic reticulum[0.316]; Cytoplasm[0.091]*
	*P41222*	*Endoplasmic reticulum; Golgi apparatus; Nucleus*	*Endoplasmic reticulum[0.237]; Nucleus[0.207]* *Extracell[0.146]; Cytoplasm[0.143]; Golgi apparatus[0.107];*
*Moderate Case* *[> = 0.08]*	*P15941*	*Cytoplasm; Nucleus*	*Plasma membrane[0.467]; Nucleus[0.178]; Cytoplasm[0.145]*
	*Q14145*	*Cytoplasm; Nucleus*	*Cytoplasm[0.520]; Nucleus[0.292]; Endoplasmic reticulum[0.089]*
	*Q86YR5*	*Endoplasmic reticulum; Golgi apparatus*	*Golgi apparatus[0.371]; Endoplasmic reticulum[0.272]; Cytoplasm[0.129];Plasma membrane[0.124]*
	*P41222*	*Endoplasmic reticulum;Golgi apparatus* *Nucleus*	*Nucleus[0.257];Endoplasmic reticulum[0.214]; Cytoplasm[0.166]; Extracell[0.103]; Golgi apparatus[0.098]*
	*Q96JC1*	*Cytoplasm; Lysosome*	*Lysosome[0.676]; Endosome[0.208]*
	*Q96EY5*	*Cytoplasm; Nucleus*	*Nucleus[0.223]; Endosome[0.202]; Golgi apparatus[0.121]* *Cytoskeleton[0.092]*
	*Q86WA9*	*Endoplasmic reticulum;Golgi apparatus* *Plasma membrane*	*Lysosome[0.642]; Endoplasmic reticulum[0.136]* *Plasma membrane[0.101]*
	*Q9NWZ5*	*Cytoplasm; Nucleus*	*Endoplasmic reticulum[0.459]; nucleus[0.320]; Cytoplasm[0.133]*
*Pessimistic Case [> = 0.07]*	*Q9UHD9*	*Cytoplasm; Nucleus*	*Endoplasmic reticulum[0.315]; Nucleus[0.284]; Cytoplasm[0.202]*
	*P30533*	*Cytoplasm; Endoplasmic reticulum*	*Endoplasmic reticulum[0.250]; Cytoplasm[0.237]* *Nucleus[0.151]; Plasma membrane[0.139]*
	*Q86YR5*	*Endoplasmic reticulum;Golgi apparatus*	*Golgi apparatus[0.421]; Endoplasmic reticulum[0.202]* *Cytoplasm[0.136]; Plasma membrane[0.106]*
	*Q9NX74*	*Cytoplasm; Endoplasmic reticulum*	*Endoplasmic reticulum[0.273]; Cytoplasm[0.271]* *Mitochondrion[0.247]*
	*P41222*	*Endoplasmic reticulum;Golgi apparatus* *Nucleus*	*Nucleus[0.224]; Endoplasmic reticulum[0.197]; Cytoplasm[0.184]; Extracell[0.126];Golgi apparatus[0.077]*
	*Q96EY5*	*Cytoplasm; Nucleus*	*Nucleus[0.246]; Endosome[0.154]; Cytoskeleton[0.095]; Golgi apparatus[0.119];Plasma membrane[0.094]; Endoplasmic reticulum[0.075]*
	*P42858*	*Cytoplasm; Nucleus*	*Nucleus[0.285]; Cytoplasm[0.216]; Endoplasmic reticulum[0.071] Golgi apparatus[0.074]; Plasma membrane[0.096]*
	*Q9Y613*	*Cytoplasm; Cytoskeleton*	*Cytoskeleton[0.530]; Cytoplasm[0.146]; Nucleus[0.111]*

Illustrations:

[1] True Subcellular Locations : denotes the labels from Hum-mPLoc 2.0 dataset (GOA database version 70.0 released March 10 2008);

[2] Cytoskeleton[0.136]:the label NOT included in the original Hum-mPLoc 2.0 dataset, but validated TRUE by the latest Swiss-Prot database ( http://www.uniprot.org/uniprot/ UniProt release 2011_11 Nov 16, 2011), where [0.136] denotes the probability that the protein is assigned to the label Cytoskeleton;

[3] Nucleus[0.115]: Non-target Label Hit (wrong prediction), NOT validated by the latest Swiss-Prot database ( http://www.uniprot.org/uniprot/ UniProt release 2011_11 Nov 16, 2011), where [0.115] denotes the probability that the protein is assigned to the label Nucleus;