. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: Arch Biochem Biophys. 2011 Nov 10;523(1):103–106. doi: 10.1016/j.abb.2011.11.001

Table 1.

Effects of vitamin D status and 1,25D3 on EAE and experimental IBD.

Model IBD	Mechanism of disease^a	1,25D3^b	VDR/D⁻	Reference(s)
IL-10 KO	T reg deficiency/gut flora	↓	– –	[45, 46]
IL-2 KO	T reg deficiency	-	-	[63]
DSS	macrophage/barrier function	↓	–	[48]
TNBS	Th1/Th17	↓	ND	[49]
T cell transfer	naïve T cell/Th17	ND	–	[46]
EAE
WT	Th1/Th17	↓	↓	[51–56, 59]
IL-4 KO	Th2 deficiency	-	ND	[65]

Mechanisism by which either IBD or EAE develops.

1,25D3: Effect of 1,25D3 or 1,25D3 agonists on disease development.

VDR/D-: Effect of VDR or vitamin D deficiency (D-) on disease development. ND: not done, -: no change in disease,↓- decreased disease, – – - increased severity of disease.