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. Author manuscript; available in PMC: 2013 Nov 16.
Published in final edited form as: Brain Res. 2012 Feb 14;1485:77–87. doi: 10.1016/j.brainres.2012.02.014

Figure 1.

Figure 1

Tonic and Phasic Inhibition in the Rat MGB. A) Voltage-clamp (CsCl based internal solution, Vhold = −60mV, ECl ≈ 0mV) recording from an MGB neuron of a 7 month old FBN rat during the application of GABA uptake blockers (NNC-711 and SNAP5114, blockers of GAT-1,2 &3 mediated GABA uptake) [black bar] and subsequent application of the GABAAR selective antagonist 50μM gabazine (SR95531) [gray bar] reveal the presence of extrasynaptic GABAARs mediating a tonic Cl− current in the MGB which is blocked by gabazine. B) Expanded sIPSCs (underlined region in A with arrowhead) are also blocked by gabazine and therefore GABAAR mediated (A). Scale bar is 50sec and 50pA for A and 100msec and 40pA for B. Modified from Richardson et al., 2011.