Figure 3.

Regulation of MGB Neuron Excitability by Activation of Extrasynaptic GABA_ARs. Whole cell recording of response from a MGB neuron of a 4 month FBN rat to a 1sec, ±100pA current injection in normal ACSF (A), the presence of 1μM gaboxadol (Bi), 5μM gaboxadol (Bii) and following a 10min washout period (C). As the concentration of gaboxadol is increased, the firing rate in response to the depolarizing pulse decreases and the resting membrane potential becomes more negative. The cell eventually responds with a single t-type Ca²⁺ dependent burst upon depolarization and remains inactive, consistent with increasing tonic inhibition and hyperpolarization. Internal solution is K-gluconate based.