Table 1.

Components of the eEF1 complex:

Current Nomenclature		Prior Nomenclature	Canonical Function
eEF1A		eEF1α	aa-tRNA delivery to the ribosome
eEF1B	eEF1Bα	eEF1β (yeast and metazoan) eEF1β’(plant)	GEF for eEF1A
	eEF1Bβ (plant)	eEF1β (plant)	GEF for eEF1A
	eEF1Bγ	eEF1γ	Structural component
	eEF1Bδ (metazoan)	eEF1δ (metazoan)	GEF for eEF1A
Val-RS (metazoan)		Val-RS	Valyl tRNA synthetase

The eukaryotic elongation factor 1 (eEF1) complex consists of eEF1A (EF-Tu in bacteria), the Gprotein involved in delivering aa-tRNA to the elongating ribosome and eEF1B (EF-Ts in bacteria), a multiprotein complex that acts as the guanine nucleotide exchange factor (GEF). In animals, Val-RS is found bound to the eEF1 complex and this complex is often called the eEF1H complex. In mammals, multiple aminoacyl-tRNA synthetases have been suggested to interact with eEF1 complex.⁸⁷