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. Author manuscript; available in PMC: 2013 Jul 17.
Published in final edited form as: Acc Chem Res. 2012 Feb 21;45(7):1067–1076. doi: 10.1021/ar2002123

Figure 1. Oligonucleotide Mechanisms of Action.

Figure 1

Four mechanisms are illustrated. In the nucleus: (i) classical antisense (ASO) mediated mRNA degradation via ribonuclease H; (ii) alteration of exon choice using splice switching oligonucleotides (SSO). In the cytosol: (iii) siRNA mediated mRNA degradation via the Ago 2/RISC complex; (iv) miRNA modulation of mRNA function.