Table 1.

Selected Examples of Biologically Active Oligonucleotide Conjugates

Oligonucleotide	Conjugation Partner	Linkage	Target	Cell Uptake Via	Reference
2’-O-Me PS SSO	Bombesin peptide	Maleimide terminated peptide linked to 5’ SH oligonucleotide	Abnormal exon in luciferase reporter	BB2 receptor	10
2’-F modified siRNA	None:chimera with RNA aptamer made by in vitro transcription	NA	Plk-1 mRNA	PSMA	48
siRNA	CpG DNA oligonucleotide	Carbon linker between the CpG and antisense siRNA strand	Stat 3 mRNA	TLR-9	53
Morpholino SSO	Novel CPP with 6-aminohexanoic acids and arginines	Amide linker	Exon and intron 23 of the mouse dystrophin gene	CPP mediated non-specific uptake	64
siRNA	Tocopherol	5’ phosphate linkage using a tocopherol phosphoramidite	ApoB mRNA	Lipoprotein Receptors?	44