. Author manuscript; available in PMC: 2012 Jun 14.

Published in final edited form as: J Mol Neurosci. 2011 May 21;45(3):409–421. doi: 10.1007/s12031-011-9549-8

Table 3.

Immunolabelling and filament dimensions of three types of neuronal cytoplasmic inclusions in NIFID

Antigen	Neuronal cytoplasmic inclusion
Antigen	LACI	TTBI	CCI
FUS	++	+++	−
α-Internexin^*	+/−	−	(+++)
Phosphorylated NEFH^*	+	++	(+++)
Ubiquitin^*	+++	+++	(++)
Polyglutamine^*	(−)	(−)	(−)
Filament width mean ± s.e.m. (range)	8.9 ± 0.2 (5.9-15.0) nm	9.6 ± 0.5 (5.6-12.4) nm	10.1 ± 0.7 (6.1-14.2) nm

Abbreviations: LACI, loosely aggregated cytoplasmic inclusion; TTBI, ‘tangled twine ball inclusion; CCI, compact cytoplasmic inclusion; FUS, fused in sarcoma; NEFH, neurofilament heavy polypeptide. Semi-quantitative assessment of the density of immunogold particles/filament: +++ high; ++ moderate; + low; +/− negligible; − unlabelled.

Data previously reported (Mosaheb et al. 2005) are included here (in parentheses) for comparison with FUS immunoelectron microscopy