(b)
| H0 | H2 | H4 | H6 | P | |||||
|---|---|---|---|---|---|---|---|---|---|
| CO (L/min) | 4.7 (2.4–11.4) | 4.7 (2.3–10.5) | 4.7 (3.3–9.2) | 5.1 (2.4–11.6) | ns | ||||
| CI (L/min/m2) | 2.5 (1.5–5.7) | 2.6 (1.2–5.3) | 2.7 (2–4.7) | 2.9 (1.6–5.8) | ns | ||||
| PCWP (mmHg) | 11 (4–27) | 10.5 (5–22) | 13 (4–20) | 11 (3–21) | ns | ||||
| CVP (mmHg) | 9 (0–15) | 8.5 (3–16) | 10 (1–14) | 11 (0–14) | ns | ||||
| SVR (dynes-s/cm5) | 1339 (89–2200) | 1125 (594–1967) | 1154 (558–1941) | 1067 (564–1901) | ns | ||||
| PVR (dynes-s/cm5) | 214 (84–564) | 206 (76–672) | 182 (60–956) | 220 (63–328) | ns | ||||
| SvO2 (%) | 71 (55–79) | 71 (54–76) | 69 (50–75) | 71 (50–75) | ns | ||||
| ScvO2 (%) | 74 (65–85) | 76 (59–87) | 69 (49–78) | 72 (48–85) | ns | ||||
| Hb (g/dL) | 10.9 (8.7–14.9) | 10.7 (8.3–14.4) | 10.7 (9–15.3) | 10.7 (8.3–13.6) | ns | ||||
| Lac (mg/dL) | 2.2 (0.9–7) | 3 (1.3–9.1)* | 3.1 (0.7–9.9)* | 3.6 (0.7–9.7)* | <0.05 | ||||
| MAP (mmHg) | 79 (66–109) | 73 (52–100) | 76 (57–99) | 77 (54–99) | ns | ||||
| MPP (mmHg) | 24 (13–33) | 23 (14–35) | 24 (17–61) | 24 (15–36) | ns | ||||
| Central temp (°C) | 37.1 (35.6–38.8) | 37.4 (36.2–39.1)* | 37.6 (36.9–38.8)∗§ | 37.6 (37.2–38.4)∗§ | <0.001 | ||||
| Periph temp (°C) | 36.7 (35–38.7) | 36.9 (35.3–38.5)** | 37 (36–38.5)∗§ | 37.2 (36.2–38.4)∗§ | <0.001 | ||||
| Central-Periph (°C) | 0.4 (0–1.3) | 0.4 (0–0.9) | 0.4 (0–1.4) | 0.4 (0–1) | ns | ||||
| DO2 (mL/min/m2) | 411 (193–721) | 411 (137–737) | 398 (278–660) | 429 (264–750) | ns | ||||
| VO2 (mL/min/m2) | 114 (61–214) | 110 (87–221) | 116 (91–237) | 129 (83–208) | ns | ||||
| O2 ER (%) | 27 (21–57) | 29 (21–71) | 29 (25–50) | 28 (21–50) | ns | ||||
|
| |||||||||
| S | NS | S | NS | S | NS | S | NS | ns | |
|
| |||||||||
| CO (L/min) | 5 (3.1–11.4) | 3.1 (2.4–4.7) | 5.1 (3.3–10.5) | 3.1 (2.3–3.9) | 4.7 (3.5–9.2) | 4.4 (3.3–4.7) | 5.6 (4.3–11.6) | 4.3 (2.4–4.4) | 0.058 |
| CI (L/min/m2) | 2.5 (1.8–5.7) | 1.8 (1.5–2.5) | 2.8 (1.9–5.3) | 1.8 (1.2–2.1) | 2.7 (2–4.7) | 2.3 (2.2–2.5) | 3.1 (2.5–5.8) | 2.3 (1.6–2.3) | 0.064 |
| PCWP (mmHg) | 12 (4–27) | 10 (8–10) | 12 (8–22) | 9 (5–10) | 13 (4–20) | 11 (8–11) | 14 (3–21) | 10 (9–11) | ns |
| CVP (mmHg) | 9 (0–15) | 8 (5–10) | 9 (4–16) | 8 (3–11) | 10 (1–13) | 9 (8–14) | 11 (0–14) | 8 (8–12) | ns |
| SVR (dynes-s/cm5) | 1144 (89–2001) | 1717 (1548–2200) | 1113 (594–1506) | 1504 (1128–1967) | 1152 (558–1941) | 1358 (1139–1525) | 1006 (564–1327) | 1580 (1325–1901) | 0.074 |
| PVR (dynes-s/cm5) | 204 (84–479) | 294 (103–564) | 192 (76–301) | 277 (167–672) | 200 (60–956) | 182 (170–286) | 221 (63–296) | 205 (163–328) | ns |
| SvO2 (%) | 71 (55–79) | 68 (42–72) | 71 (54–76) | 59 (29–73) | 70 (50–75) | 66 (63–74) | 71 (50–75) | 71 (66–77) | ns |
| ScvO2 (%) | 74 (60–87) | 70 (45–73) | 75 (61–87) | 59 (29–82) | 71(49–82) | 66 (60–69) | 72 (48–85) | 64(60–68) | 0.035 |
| Hb (g/dL) | 11.3 (8.7–14.9) | 10.9 (9.4–12.1) | 10.9 (8.3–14.4) | 10.2 (8.3–11.9) | 11 (9–15.3) | 9.9 (9.1–10.5) | 10.7 (8.3–13.6) | 11.9 (10.2–12.4) | ns |
| Lac (mg/dL) | 1.9 (0.9–7) | 2.9 (1.2–6.6) | 2.6 (1.3–9.1) | 5.5 (2.1–7.7) | 3.2 (0.7–9.9) | 3 (1.9–8.2) | 3.7 (0.7–9.7) | 2.1 (1.7–6.6) | 0.076 |
| MAP (mmHg) | 81 (66–109) | 74 (70–107) | 75 (60–100) | 66 (52–84) | 75 (57–99) | 76 (65–98) | 76 (54–93) | 79 (66–99) | ns |
| MPP (mmHg) | 25 (13–33) | 23 (14–29) | 26 (20–35) | 18 (14–25) | 25 (17–61) | 21 (20–21) | 26 (15–36) | 20 (19–21) | ns |
| Central temp (°C) | 36.9 (35.7–38.8) | 37.3 (35.6–37.7) | 37.4 (36.2–37.1) | 36.7 (36.5–38.1) | 37.7 (37–38.8) | 37 (36.9–37.1) | 37.6 (37.2–38.4) | 37.6 (37.5–37.6) | ns |
| Periph temp (°C) | 36.7 (35.3–38.7) | 36.9 (35.2–37.2) | 37 (35.9–38.5) | 36.4 (36.1–37.2) | 37.2 (36.2–38.5) | 36.7 (36.6–36.8) | 37.2 (36.4–38.4) | 37.2 (37.1–37.2) | ns |
| Central-Periph (°C) | 0.2 (0–1.3) | 0.45 (0.4–0.5) | 0.5 (0–0.8) | 0.4 (0.3–0.9) | 0.5 (0–1.4) | 0.3 (0.2–0.3) | 0.4 (0–1) | 0.5 (0.4–0.5) | ns |
| DO2 (mL/min/m2) | 457 (292–721) | 255 (193–416) | 417 (281–737) | 252 (137–340) | 421 (335–660) | 316 (278–361) | 431 (350–750) | 356 (323–389) | ns |
| VO2 (mL/min/m2) | 118 (76–214) | 107 (61–113) | 118 (94–221) | 96 (87–109) | 117 (99–238) | 93 (91–117) | 136 (97–208) | 96 (83–109) | ns |
| O2 ER (%) | 27 (21–43) | 31 (27–57) | 29 (21–45) | 40 (25–70) | 29 (25–50) | 34 (25–37) | 28 (24–50) | 28 (21–34) | ns |
CI: cardiac index, CO: cardiac output, CVP: central venous pressure, DO2: whole-body oxygen delivery, Hb: hemoglobin, Lac: lactate, MAP: mean arterial pressure, MPP: mean pulmonary pressure, O2ER: oxygen extraction ratio, PCWP: pulmonary capillary wedge pressure, PVR: pulmonary vascular resistance, ScvO2: central venous oxygen saturation, SvO2: mixed venous oxygen saturation, SVR: systematic vascular resistance, temp: temperature, VO2: whole-body oxygen consumption. *P < 0.01 from H0, **P < 0.05 from H0, § P < 0.01 from H2, §§ P < 0.05 from H2, † P < 0.01 from H4, †† P < 0.05 from H4.