Table 3.
AST |
ALT |
|||||
Estimate | 95% CI | Pvalue | Estimate | 95% CI | Pvalue | |
Age (yr) | -0.27 ± 0.09 | -0.45 - -0.09 | 0.0034 | -0.55 ± 0.14 | -0.81 - -0.27 | 0.0001 |
TS (%) | 0.14 ± 0.07 | -0.01 - 0.29 | 0.063 | 0.28 ± 0.11 | 0.05 - 0.50 | 0.016 |
Ferritin (ng/mL) | 0.01 ± 0.001 | 0.008 - 0.012 | < 0.0001 | 0.01 ± 0.001 | 0.009 - 0.014 | < 0.0001 |
GGT (IU/mL) | 0.10 ± 0.03 | 0.03 - 0.16 | 0.003 | 0.20 ± 0.05 | 0.10 - 0.29 | < 0.0001 |
BMI (kg/m2) | 0.86 ± 0.42 | 0.03 - 1.69 | 0.042 | 3.36 ± 0.63 | 2.12 - 4.60 | < 0.0001 |
PNPLA3 genotype (per p.148M allele) | 5.46 ± 1.68 | 2.15 - 8.67 | 0.0014 | 6.05 ± 2.51 | 1.09 - 11.00 | 0.017 |
AST: Aspartate aminotransferase; ALT: Alanine aminotransaminase; CI: Confidence interval; TS: Transferrin saturation; GGT: γ-glutamyl transferase; BMI: Body mass index; p.148M: PNPLA3 rs738409 148Met protein variant.