Synthesis of {(1R,2R,4R)-4-Methyl-1,2-cyclohexanediamine}oxalatoplatinum(II), 3aa
a(i) H2O2/HCOOH, (ii) MsCl/Py, NaN3, (iii) Pd/CaCO3, H2 (3 bar), (iv) l-tartaric acid, (v) K2PtCl4/NaOH (0.25 M), and (vi) AgNO3, potassium oxalate. Structures of 4-ethyl- and 4-t-butyl oxaliplatin derivatives 4 and 5, synthesized as enantiomeric mixtures (all substituents at the cyclohexane ring in equatorial positions).