Figure 1.

Cortico-striato-thalamocortical circuit. Schematic diagram of the cortico-striato-thalamocortical (CSTC) circuit, which is implicated in the pathophysiology of OCD. In DBS for OCD, activity within this circuit is thought to be modulated by high frequency stimulation. DLPFC, dorsolateral prefrontal cortex; ACC, anterior cingulate cortex; OFC, orbitofrontal cortex; VMPFC, ventromedial prefrontal cortex. Arrowheads indicate direction of neural input. Black lines represent connections among the major structures implicated in DBS for OCD; gray lines indicate additional connections.