. 2012 Jun 14;6:29. doi: 10.3389/fnint.2012.00029

Table 1.

Mechanisms of action of DBS.

Mechanisms of action of DBS
Local inhibition –Conduction block –Buildup of K+ in submyelin space –Inactivation of Na+ channels –Depletion of neurotransmitter (glutamate) –Release of inhibitory neurotransmitters –Adenosine –GABA –Hyperpolarization of soma Local excitation –Axonal activation –antidromic –orthodromic –Glutamate release from astrocytes Modulation of temporal firing pattern –Desynchronization of neural firing –Suppression of information transmission through region Neurogenesis –Generation of DGCs –Integration of DGCs into hippocampal circuits

Mechanisms of action of DBS

Local inhibition
- –Conduction block
  - –Buildup of K+ in submyelin space
  - –Inactivation of Na+ channels
- –Depletion of neurotransmitter (glutamate)
- –Release of inhibitory neurotransmitters
  - –Adenosine
  - –GABA
- –Hyperpolarization of soma
Local excitation
- –Axonal activation
  - –antidromic
  - –orthodromic
- –Glutamate release from astrocytes
Modulation of temporal firing pattern
- –Desynchronization of neural firing
- –Suppression of information transmission through region
Neurogenesis
- –Generation of DGCs
- –Integration of DGCs into hippocampal circuits

DGCs: dentate gyrus cells.