Table 2.
Findings of functional imaging studies during stimulation of DBS targets used for OCD.
| STN DBS | ALIC DBS | VC/VS DBS | |
|---|---|---|---|
| Medial PFC | ↓ Mallet et al., 2007 | — | — |
| DLPFC | — | ↑↓ Baker et al., 2007; Van Laere et al., 2006 | — |
| ACC | ↓ Mallet et al., 2007; Le Jeune et al., 2010 | ↑↓ Baker et al., 2007; Van Laere et al., 2006 | ↑ Baker et al., 2007 |
| Posterior cingulate | — | ↑ Baker et al., 2007 | ↑ Baker et al., 2007 |
| OFC | — | ↓ Abelson et al., 2005 | ↑ Rauch et al., 2006 |
| Medial frontal gyrus | ↓ Le Jeune et al., 2010 | — | — |
| Superior frontal gyrus | — | — | ↑ Baker et al., 2007 |
| Middle frontal gyrus | ↑ Baker et al., 2007 | — | ↑ Baker et al., 2007 |
| Inferior frontal gyrus | ↑ Mallet et al., 2007 | — | ↑ Baker et al., 2007 |
| Frontal cortex | — | ↑↓ Nuttin et al., 2003 | — |
| Insula | — | ↓ Van Laere et al., 2006 | — |
| Inferior parietal gyrus | ↑ Mallet et al., 2007 | — | — |
| Superior temporal gyrus | — | ↑ Nuttin et al., 2003 | — |
| Middle temporal gyrus | ↑↓ Mallet et al., 2007 | ↑ Nuttin et al., 2003 | — |
| Inferior temporal gyrus | ↑ Mallet et al., 2007 | — | — |
| Middle occipital gyrus | ↓ Mallet et al., 2007 | — | — |
| Lateral occipital cortex | — | ↑ Nuttin et al., 2003 | — |
| Bilateral cuneus | ↓ Mallet et al., 2007 | — | — |
| Striatum | — | ↑↓ Nuttin et al., 2003; Van Laere et al., 2006 | — |
| Caudate | — | ↑ Baker et al., 2007 | ↑ Baker et al., 2007 |
| Globus pallidus | — | ↑ Baker et al., 2007 | ↑ Rauch et al., 2006 |
| Putamen | — | ↑ Baker et al., 2007 | ↑ Baker et al., 2007; Rauch et al., 2006 |
| Amygdala | — | ↓ Van Laere et al., 2006 | — |
| Thalamus | ↑ Mallet et al., 2007 | ↑↓ Baker et al., 2007; Van Laere et al., 2006 | ↑ Baker et al., 2007; Rauch et al., 2006 |
| Pons | — | ↑ Nuttin et al., 2003 | — |
| Correlation with clinical improvement | Decrease in OFC/ventral medial PFC correlated with decrease in Y-BOCS scores (Le Jeune et al., 2010) | Decrease in OFC metabolism seen in patients with clinical improvement (Abelson et al., 2005); negative correlation of decreased left hippocampus and left posterior cingulate metabolism with Y-BOCS scores, positive correlation of reduced left amygdala and left head of the caudate neucleus metabolism with decrease in Y-BOCS (Van Laere et al., 2006) | — |
Arrows indicate direction of change in activity with stimulation of the indicated target.