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. Author manuscript; available in PMC: 2012 Jun 14.
Published in final edited form as: Annu Rev Pathol. 2010;5:51–75. doi: 10.1146/annurev-pathol-121808-102113

Table 1.

Cancer Genome – Sequencing Studies

Study type Number of genes screened Total number of mutations Number of genes mutated Average number of mutations per tumor Estimated number of driver mutations Reference(s)
Exomic
Breast (n = 11) 18,191 1243 1137 84 140 87, 88
Colorectal (n = 11) 18,191 942 848 76 140 87, 88
Diverse (n = 210) 518 798 581 119 94
Pancreatic (n = 24) 20,661 1163 1007 48 160 98
Glioblastoma (n = 21) 20,661 748 685 47 155 102
Glioblastoma (n = 91) 601 453 223 8 103
Lung (n = 188) 623 1013 348 26 108
Genomic
Acute myeloid leukemia (n = 1) 500–1000 10 Not applicable 10 82