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Complex structure of human Hint1 with Lys-AMS, Ala-AMS, and Trp-AMS. (A) Dimeric structure of Hint1 in complex with Lys-AMS. One subunit of the Hint1 dimer contains the ligand. (B–D) Electron density maps of the bound aa-AMS analogues. The refined 2Fo-Fc density maps are shown at 1.0 σ. Chemical structures of the analogues are shown on the right, with electron densities missing from the side chains highlighted by shading on the chemical structures.
