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. Author manuscript; available in PMC: 2012 Jun 14.
Published in final edited form as: Chem Soc Rev. 2012 Apr 13;41(10):3912–3928. doi: 10.1039/c2cs15331a

Figure 6.

Figure 6

Microfluidic technologies underdevelopment for MS-based single cell analysis. A. Mass spectra of 1 nM leucine enkephalin directly infused from a microchip (schematic shown in inset) at 50 nL/min. Signal was averaged for 30 s (top) and 0.2 s (bottom). Figure 6B. Nearly dilution-free analysis of subnanoliter aqueous plugs by nanoESI-MS. Figure 6C. Valve-based droplet generation enabling controlled reagent mixing for in-droplet sample preparation. Droplets 1 – 6 contain different ratios of dye molecules for demonstration. (6B adapted from 89)