Figure 6.

Sequential spectral-domain optical coherence tomography (OCT) scans of a 75-year-old woman with subfoveal choroidal neovascularization (CNV). A baseline scan depicted an elevation of the retinal pigment epithelium (RPE) layer, a localized fusiform thickening and duplication of the highly reflective external band (RPE/choriocapillaris complex), and intraretinal fluid corresponding to CNV. The patient was treated with intravitreous injection of ranibizumab at baseline, month 1, and month 2. Three months after the first injection, the OCT scan demonstrated improvement of macular architecture with mild intraretinal fluid. Additionally, the thickness map showed a signifi-cant decrease in the retinal thickness at the macular region. Between 3 and 12 months after treatment, three injections were administered due to the presence of discrete intraretinal fluid. It is important to note the better resolution of the 12-month scan due to image oversampling. The improvement in the resolution leads to a better visualization of retinal layers and it is possible to note the inner/outer segment junction interruption. At 15 months from the first injection, the patient presented intraretinal fluid and was treated with intravitreous ranibizumab. At 18 months of follow-up, no fluid was detected in the macular area, but the thickness map showed a diffuse thinning.