Table 5.

Frequency of micronuclei in the bone marrow of mice treated with CP-31398

Treatment	Sex	Dose (mg/kg)	Time in Hours	n	PCE/RBC (%) Mean ± S.E.	PCE with MN (%) Mean ± S.E.
Control	Male	0	24	5	51.85 ± 0.89	0.15 ± 0.03
CP-31398	Male	250	24	5	49.73 ± 1.11	0.13 ± 0.03
CP-31398	Male	500	24	5	47.21 ± 1.59	0.15 ± 0.02
CP-31398	Male	1000	24	4	47.97 ± 0.67	0.14 ± 0.05
Urethane	Male	300	24	5	47.11 ± 0.70	2.36 ± 0.30**
Control	Female	0	24	5	49.83 ± 1.59	0.12 ± 0.03
CP-31398	Female	250	24	5	51.16 ± 1.05	0.06 ± 0.02
CP-31398	Female	500	24	5	53.78 ± 1.62	0.11 ± 0.04
CP-31398	Female	1000	24	5	52.16 ± 0.99	0.14 ± 0.05
Control	Male	0	48	4	44.18 ± 4.94	0.11 ± 0.02
CP-31398	Male	250	48	5	48.96 ± 0.75	0.04 ± 0.02
CP-31398	Male	500	48	5	46.91 ± 2.52	0.06 ± 0.02
CP-31398	Male	1000	48	4	46.82 ± 2.71	0.16 ± 0.04
Control	Female	0	48	5	55.43 ± 3.50	0.07 ± 0.01
CP-31398	Female	250	48	5	51.24 ± 1.06	0.12 ± 0.03
CP-31398	Female	500	48	5	52.39 ± 2.75	0.14 ± 0.01
CP-31398	Female	1000	48	5	50.29 ± 2.56	0.05 ± 0.02

n = Number of surviving animals; PCE = Polychromatic erythrocytes; RBC= Red blood cells; MN = Micronuclei; Control = 0.5% Methyl Cellulose;

^*= p < 0.05 by test for binomial proportions for test article;

^**= p < 0.01 by test for binomial proportions for positive control