Table 6.

Frequency of micronuclei in the bone marrow of mice treated with SHetA2

Treatment	Sex	Dose (mg/kg)	Time in Hours	n	PCE/RBC (%) Mean ± S.E.	PCE with MN (%) Mean ± S.E.
Control	Male	0	24	5	48.89 ± 0.71	0.13 ± 0.02
SHetA2	Male	330	24	5	50.23 ± 1.12	0.18 ± 0.06
SHetA2	Male	660	24	5	49.93 ± 0.99	0.25 ± 0.06 *
SHetA2	Male	1320	24	5	35.18 ± 6.83	0.23 ± 0.04
Urethane	Male	300	24	5	49.95 ± 1.62	3.28 ± 0.30**
Control	Female	0	24	5	51.87 ± 1.97	0.15 ± 0.03
SHetA2	Female	330	24	5	53.18 ± 1.65	0.09 ± 0.02
SHetA2	Female	660	24	5	49.62 ± 0.87	0.10 ± 0.03
SHetA2	Female	1320	24	5	49.59 ± 1.16	0.11 ± 0.02
Control	Male	0	48	5	47.40 ± 2.41	0.14 ± 0.04
SHetA2	Male	330	48	5	51.64 ± 2.86	0.12 ± 0.03
SHetA2	Male	660	48	5	53.50 ± 1.89	0.11 ± 0.04
SHetA2	Male	1320	48	5	50.07 ± 0.55	0.18 ± 0.04
Control	Female	0	48	5	48.87 ± 1.03	0.14 ± 0.04
SHetA2	Female	330	48	5	53.63 ± 1.58	0.13 ± 0.04
SHetA2	Female	660	48	5	48.19 ± 0.90	0.11 ± 0.02
SHetA2	Female	1320	48	5	47.01 ± 2.24	0.17 ± 0.04

n = Number of surviving animals; PCE = Polychromatic erythrocytes; RBC= Red blood cells; MN = Micronuclei; Control = 0.5% Methyl Cellulose;

^*= p < 0.05 by test for binomial proportions for test article;

^**= p < 0.01 by test for binomial proportions for positive control