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. Author manuscript; available in PMC: 2013 Jul 4.
Published in final edited form as: Mutat Res. 2012 Apr 10;746(1):78–88. doi: 10.1016/j.mrgentox.2012.03.009

Table 7.

Frequency of micronuclei in the bone marrow of mice treated with phospho-ibuprofen

Treatment Sex Dose (mg/kg) Time in Hours n PCE/RBC (%) Mean ± S.E. PCE with MN (%) Mean ± S.E.
Control Male 0 24 5 47.46 ± 3.03 0.15 ± 0.03
Phospho-Ibuprofen Male 500 24 5 52.60 ± 2.42 0.10 ± 0.03
Phospho-Ibuprofen Male 1000 24 5 49.02 ± 2.63 0.10 ± 0.02
Phospho-Ibuprofen Male 2000A 24 4 49.94 ± 2.33 0.21 ± 0.06
Urethane Male 300 24 5 51.10 ± 2.39 2.17 ± 0.26**
Control Female 0 24 5 48.54 ± 1.64 0.12 ± 0.04
Phospho-Ibuprofen Female 500 24 5 44.84 ± 1.74 0.13 ± 0.05
Phospho-Ibuprofen Female 1000 24 5 50.10 ± 0.53 0.15 ± 0.02
Phospho-Ibuprofen Female 2000 24 5 53.44 ± 4.86 0.20 ± 0.02
Control Male 0 48 5 48.33 ± 1.57 0.14 ± 0.02
Phospho-Ibuprofen Male 500 48 5 50.95 ± 2.77 0.04 ± 0.02
Phospho-Ibuprofen Male 1000 48 5 52.31 ± 2.86 0.12 ± 0.03
Phospho-Ibuprofen Male 2000 48 5 46.94 ± 2.55 0.18 ± 0.01
Control Female 0 48 5 49.61 ± 2.76 0.11 ± 0.04
Phospho-Ibuprofen Female 500 48 5 51.92 ± 3.84 0.18 ± 0.05
Phospho-Ibuprofen Female 1000 48 5 46.36 ± 1.53 0.11 ± 0.03
Phospho-Ibuprofen Female 2000 48 5 46.95 ± 0.91 0.08 ± 0.03
A

= One male mouse in this group found dead before necropsy; n = Number of surviving animals; PCE = Polychromatic erythrocytes; RBC= Red blood cells; MN = Micronuclei; Control = PEG 400;

*

= p < 0.05 by test for binomial proportions for test article;

**

= p < 0.01 by test for binomial proportions for positive control