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. Author manuscript; available in PMC: 2013 Jul 4.
Published in final edited form as: Mutat Res. 2012 Apr 10;746(1):78–88. doi: 10.1016/j.mrgentox.2012.03.009

Table 8.

Polyploidy index in CHO cells treated with CP31398, SHetA2 or Phospho-ibuprofen

Exposure CP-31398 SHetA2 Phospho-ibuprofen
Concentration μg/ml Polyploidy Index (%) Concentration μg/ml Polyploidy Index (%) Concentration μg/ml Polyploidy Index (%)
3 Hr −S9 Sterile Water 0.5 DMSO 0.9 DMSO 1.4
2.5 1.0 1 0.9 6.25 0.5
5 0.0 2 0.0 12.5 1.4
10 0.5 4 0.9 25 1.4
MMS, 50 μg/ml 0.5 MMS, 50 μg/ml 0.5 MMS, 50 μg/ml 0.4
3 Hr +S9 Sterile Water 0.5 DMSO 0.0 DMSO 0.5
10 0.0 16 0.0 25 0.9
20 0.5 32 1.0 50 1.4
40 0.5 64 0.0 100 0.9
CP, 12.5 μg/ml 0.0 CP, 12.5 μg/ml 0.0 CP, 12.5 μg/ml 0.5
21 Hr −S9 Sterile Water 0.0 DMSO 0.0 DMSO 1.0
1.25 1.5 0.4 0.0 3.125 0.5
2.5 1.0 0.8 1.0 6.25 1.5
5 0.0 1.6 0.0 12.5 1.0
MMS, 20 μg/ml 0.0 MMS, 25 μg/ml 0.0 MMS, 30 μg/ml 0.5
3 Hr +S9 Sterile Water 0.5 DMSO 1.4 DMSO 1.9
10 1.5 16 0.9 3.125 1.0
20 0.0 32 1.4 6.25 1.5
40 1.5 64 0.0 12.5 0.5
CP, 12.5 μg/ml 0.0 CP, 12.5 μg/ml 0.0 25 0.5
50 1.0
100 1.9
CP, 12.5 μg/ml 0.5

DMSO= Dimethyl sulfoxide; MMS= Methyl methanesulfonate; CP= Cyclophosphamide; S9 = Rat hepatic metabolic activation.