Skip to main content
. Author manuscript; available in PMC: 2013 Jul 4.
Published in final edited form as: Mutat Res. 2012 Apr 10;746(1):78–88. doi: 10.1016/j.mrgentox.2012.03.009

Table 9.

Polyploidy index in Chinese hamster ovary cells treated with DEPBA, Ibuprofen and PI

Exposure DEPBA Ibuprofen & PI
Concentration μg/ml Polyploidy Index (%) Concentration μg/ml Polyploidy Index (%)
3 Hr +S9 DMSO 2.0 DMSO 0.9
13.3 1.5 Ibuprofen, 62.5 0.5
26.5 2.0 Ibuprofen, 125 1.4
53 1.5 Ibuprofen, 250 1.4
500 2.4 PI, 25 0.5
5000 0.9 PI, 50 1.9
CP, 12.5 μg/ml 0.0 PI, 100 1.4
CP, 9 μg/ml 0.5
3 Hr +S9 DMSO 1.0
13.3 1.0
26.5 3.0
53 0.5
500 2.0
5000 1.5
CP, 12.5 μg/ml 0.5

DMSO= Dimethyl sulfoxide; CP= Cyclophosphamide; S9 = rat hepatic S9 metabolic activation. PI= Phospho-ibuprofen