Table 3.
Electrochemistry comparisons between kindled animals and surgical controls measured in hippocampal subfields after a 30-day latent period following amygdalar kindling
| Measure | Region | Ipsilateral
|
Contralateral
|
||
|---|---|---|---|---|---|
| Kindled | Control | Kindled | Control | ||
| Tonic glutamate level | DG | 5.77 ± 1.80 (12) | 2.26 ± 0.60 (11) | 1.84 ± 0.27 (8) | 2.81 ± 0.91 (5) |
| CA3 | 3.48 ± 0.94 (10) | 2.24 ± 0.55 (6) | 1.57 ± 0.41 (4) | 1.87 ± 0.72 (5) | |
| CA1 | 3.20 ± 0.94 (9) | 3.07 ± 1.18 (6) | 3.20 ± 0.94 (9) | 2.87 ± 1.24 (6) | |
| K+-evoked peak amplitude | DG | 5.40 ± 1.85 (11) | 6.22 ± 0.94 (11) | 4.70 ± 1.10 (8) | 4.11 ± 0.97 (8) |
| CA3 | 5.09 ± 1.13 (10) | 6.60 ± 1.73 (10) | 4.38 ± 1.58 (6) | 8.51 ± 3.44 (6) | |
| CA1 | 5.97 ± 1.38 (9) | 9.91 ± 3.37 (9) | 5.67 ± 1.63 (7) | 4.72 ± 1.36 (6) | |
| K+-evoked peak area | DG | 22.11 ± 9.62 (12) | 28.22 ± 10.62 (11) | 25.21 ± 7.25 (7) | 11.93 ± 5.71 (5) |
| CA3 | 18.20 ± 4.01 (10) | 61.35 ± 21.09 (10) | 29.26 ± 9.08 (6) | 10.36 ± 2.80 (5) | |
| CA1 | 25.75 ± 4.30 (9) | 30.69 ± 8.57 (7) | 16.93 ± 6.58 (7) | 21.18 ± 5.89 (6) | |
Microelectrode arrays were used to detect resting (tonic) glutamate levels and (phasic) K+-evoked release of glutamate in hippocampal subfields of kindled and control animals as described in Methods. Quantities expressed are micromolar; (n) = number of animals. There were no differences in a region across hemispheres and between kindled and control.