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Nitrazepam induces dose-dependent increases of TST immobility time in Usp46 mutant mice (MT). Data are expressed as mean + S.E.M. for 6 mice in each group. ## P<0.01 compared with the wild-type mice for each dose; *P<0.05, **P<0.01 (two-way ANOVA with Bonferroni’s test).
