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. 2012 Jun 14;7(6):e39084. doi: 10.1371/journal.pone.0039084

Figure 4. Effects of administration of nitrazepam and flumazenil on tail suspension test (TST) immobility time.

Figure 4

Nitrazepam (1 mg/kg) causes a significant increase in immobility time in the TST, which was blocked by flumazenil (10 mg/kg) in both the Usp46 mutant (MT) and in the Usp46 KO mice (KO). In the wild-type mice (WT), no significant effects were observed with either single administration of nitrazepam, or co-administration of nitrazepam and flumazenil. Data are expressed as mean + S.E.M. for 5–6 mice in each group. *P<0.05, **P<0.01 (two-way ANOVA with Bonferroni’s test).