Table 1. Effects of nitrazepam (1 mg/kg) and flumazenil (10 mg/kg) on general behaviors in OFT.
| Behavior | Genotype | Saline | Nitrazepam | Nitrazepam +Flumazenil |
| TotalActivity (cm) | WT (6) | 1489.9±191.4 | 1807.7±151.2 | 1296.7±83.8** |
| MT (6) | 2142.5±115.3 | 1840.8±173.4 | 1670.6±433.6 | |
| KO (5) | 2417.6±223.3 | 1763.8±194.4 | 2421.1±440.0 | |
| Rearing +Climbing | WT (6) | 17.3±5.6 | 32.5±3.4 | 19.0±2.2 |
| MT (6) | 29.3±4.2 | 21.3±3.9 | 24.6±6.6 | |
| KO (5) | 33.0±5.6 | 29.0±5.5 | 39.6±6.3* | |
| Grooming | WT (6) | 1.2±0.3 | 1.0±0.4 | 2.6±0.9 |
| MT (6) | 1.0±0.3 | 0.8±0.2 | 2.0±0.6 | |
| KO (5) | 1.2±0.5 | 1.2±0.3 | 2.8±0.7 |
Data are shown as the mean ± S.E.M. The number of animals is given in parentheses. **P<0.01 compared with the saline-treated group in wild-type (WT) mice, *P<0.05 compared with the saline-treated group in the Usp46 KO mice (KO) (Tukey-Kramer post-hoc test).