Table 4. Comparison of mean IC50 titers of superinfected and singly infected study subjects against heterologous and autologous viruses.
Subject ID | Plasma sample | Mean IC50 against heterologous viruses (n = 6) | Fold increase | Mean IC50 against autologous pseudoviruses (n = 8–12) | Fold increase |
Superinfected | |||||
CMNYU107 | First plasma | 10 | 55 | 10 | 4 |
Last plasma | 550* | 38* | |||
CMNYU6518 | First plasma | 38 | 12 | 12 | 8 |
Last plasma | 459* | 92* | |||
CMNYU129 | First plasma | 10 | 0 | 32 | 4 |
Last plasma | 10 | 123 | |||
CMNYU6544 | First plasma | 10 | 25 | 54 | 0 |
Last plasma | 251* | 47 | |||
Singly-infected | |||||
CMNYU133 | First plasma | 21 | 0 | 236 | 2 |
Last plasma | 10 | 442* | |||
CMNYU179 | First plasma | 10 | 0 | 14 | 4 |
Last plasma | 10 | 57* | |||
CMNYU153 | First plasma | 13 | 0 | 10 | 5 |
Last plasma | 15 | 47* | |||
CMNYU6542 | First plasma | 16 | 0 | 13 | 37 |
Last plasma | 12 | 483* |
IC50 titers against heterologous viruses were taken from the following publication: Powell, R. L., T. Kinge, and P. N. Nyambi. 2010. Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virus.