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. 2012 Jun 14;7(6):e38048. doi: 10.1371/journal.pone.0038048

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(A) Bone marrow-derived macrophages isolated from TRAF6 knock out (TRAF6 KO) mice were treated with TRAIL (500 ng/ml) or RANKL (100 ng/ml) with M-CSF (200 ng/ml) for 7 days. After incubation, cells were subjected to the TRAP assay. Cell morphology was examined by light microscopy, and the number of TRAP-positive multinuclear cells was quantified. (B). TRAIL-induced formation of osteoclast-like multinucleated cells from bone marrow-derived macrophages isolated from wild type and TRAF6 KO mice. Data in (B) represent the mean±SD from three independent experiments. *p < 0.005.