Table 3. Ubp5p-dependent gene expressions at 30°C.
| Category | Gene ID* | Fold change ubp5?/WT | P value | Functional annotation* |
| Carbohydrate/amino acid metabolism | CNAG_00269 | 1.80 | 8.30E-09 | Sorbitol dehydrogenase |
| CNC05840 | 1.50 | 4.60E-07 | Glycosyl hydrolase | |
| CNAG_06035 | 1.49 | 2.00E-08 | Alcohol dehydrogenase | |
| CNC01140 | 1.38 | 3.00E-10 | Lipase | |
| CNB00370 | 1.29 | 1.80E-07 | Fatty acid beta-oxidation-related protein | |
| CNE01100 | 0.71 | 1.50E-09 | long-chain-fatty-acid-CoA ligase | |
| CND00530 | 0.72 | 8.90E-07 | Urea transporter | |
| CNC06440 | 0.70 | 4.80E-08 | Inositol-3-phosphate synthase | |
| CNJ02210 | 0.63 | 7.10E-07 | Spermine transporter | |
| CNJ02220 | 0.59 | 1.70E-09 | Adenine nucleotide transporter, involved in beta-oxidationof medium-chain fatty acid | |
| CNJ01880 | 0.50 | 4.40E-09 | Ammonium transporter (AMT2) | |
| Cell wall/membrane organization | CNE03150 | 2.73 | 7.00E-12 | 1,3-beta-glucanase, involved in cell wall beta-glucanassembly (Exg1p) |
| CNE03240 | 2.54 | 2.00E-18 | Chitin synthase (Chs7p) | |
| CNAG_06031 | 1.82 | 2.00E-12 | Beta-glucan synthesis-associated protein | |
| CNAG_04270 | 1.54 | 1.80E-09 | SNAP receptor, mediate membrane fusion | |
| CNI02290 | 1.47 | 4.80E-08 | Polysaccharide synthase (Cps1p) | |
| CNF01800 | 1.45 | 4.70E-07 | Chitin deacetylase | |
| CNN00660 | 1.42 | 1.30E-08 | Glucan 1,3 beta-glucosidase protein putative | |
| Ion transport andmetabolism | CNL05450 | 2.30 | 8.00E-10 | Sodium, inorganic phosphate symporter |
| CNAG_04337 | 1.65 | 1.00E-14 | Cation diffusion facilitator | |
| CNK01330 | 1.53 | 4.00E-11 | Calcium ion transporter | |
| CND00150 | 1.52 | 5.40E-09 | Ferric chelate reductase (Fre7p) | |
| CNE04050 | 1.43 | 2.00E-12 | Iron ion transport-related protein | |
| DNA replication and repair | CNAG_04696 | 1.91 | 1.00E-13 | DNA clamp loader |
| CNI04060 | 1.38 | 5.00E-10 | Mitochondrial genome maintenance protein | |
| CNN01100 | 0.73 | 1.10E-06 | Telomere maintenance protein | |
| CNN01650 | 0.62 | 4.70E-08 | DNA dependent ATPase for DNA repair (Rad26p) | |
| Transcriptional regulation | CNK03060 | 1.43 | 8.40E-09 | C2H2 zinc finger protein Zas1 |
| CNAG_04403 | 1.43 | 9.80E-08 | CCCH zinc finger protein | |
| CNB03490 | 0.64 | 3.70E-08 | Transcriptional regulator | |
| Stress response | CNAG_07836 | 1.94 | 2.00E-12 | NAD binding dehydrogenase with oxidoreductase activity |
| CNAG_04521 | 1.47 | 3.70E-09 | Apoptosis-Inducing Factor (Aif1p) | |
| CNL03740 | 1.36 | 3.90E-07 | Catalase | |
| CNI01590 | 1.29 | 1.00E-08 | Manganese superoxide dismutase (SOD2p) | |
| CNL04910 | 0.66 | 1.10E-09 | Multidrug transporter of the major facilitator superfamily (Qdr3p) | |
| Signal pathway | CND06250 | 1.43 | 5.80E-06 | MAP kinase kinase kinase |
| CNAG_00802 | 1.39 | 3.90E-06 | Calcineurin-binding protein (Cbp1p) | |
| Cell cycle | CNG01990 | 1.62 | 8.00E-11 | G1/s-specific cyclin pcl1 (cyclin hcs26) |
| CNI01430 | 1.32 | 7.70E-06 | Cyclin-dependent protein kinase regulator | |
| Other | CNE02820 | 1.59 | 1.30E-09 | AFG1-family ATPase |
| CNAG_06009 | 1.53 | 1.10E-09 | Cyclohydrolase | |
| CNC02450 | 1.48 | 1.50E-06 | Water channel | |
| CNL04120 | 0.54 | 2.00E-10 | Adenosylmethionine-dependent methyltransferase |
*
Gene ID and functional annotation obtained from NCBI database (http://www.ncbi.nlm.nih.gov/) or Broad database (http://www.broadinstitute.org/annotation/genome/cryptococcus_neoformans/) with additional hand editing.