Figure 8. Proposed model for the regulation of hepatic steatosis by sEH in mice.

Long-term HF diet increases sEH protein level in the liver and leads to hepatic lipid accumulation and obesity with increased macrophage infiltration in white adipose tissue. sEH inhibition or deficiency reduces HF-diet–induced hepatic steatosis by inhibiting systemic inflammation, especially in adipose tissue and liver (long term) as one possible mechanism. sEH overexpression in the liver with adenovirus injection increased inflammation and hepatic lipid accumulation.