Table 1. YfiR-insensitive YfiN alleles.
Location in YfiN | Residue change | Notes |
First TM helix | A33T | |
V40A | ||
PAS, dimerization interface | P51S | |
R58C | ||
S59P | Equivalent mutation activates AwsX [35]. | |
Y62H | ||
A66V | ||
A67P | ||
A67V | ||
V68A | ||
F70L | ||
E87K | Mutation present in Clin110. | |
Second TM helix | G162S | |
A171V | ||
G173S | ||
G173D | Mutation present in SCV20265. | |
HAMP | D204N | Mutation at the equivalent position activates Tsr [59]. |
A226T | ||
L228F | ||
E232D | Mutation at the equivalent position activates NarX [58]. |
PAS refers to the periplasmic PAS domain; HAMP refers to the HAMP domain.