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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Pharm Sci. 2011 Mar 15;100(8):3345–3356. doi: 10.1002/jps.22529

Table 1.

Formulation Variables and Their Levels in the Experimental Design

Variables Low Medium High
Independent variables
X1, BSA concentration (mg/mL) 1 5 9
X2, pH of the aqueous phase 1 3 5
X3, Softisan 100 amount (mg/mL) 1 10.5 20
Coded values −1 0 +1

Dependent variable: Y1, SLN’s size (nm)