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. Author manuscript; available in PMC: 2013 Apr 26.
Published in final edited form as: J Med Chem. 2012 Apr 6;55(8):3739–3755. doi: 10.1021/jm201608g

Table 2.

MICs of (R)-12, (R)-13, and representative antimycobacterial agents (clinically used) for Mycobacterium species including drug-resistant strains.

Entry Species and strain MIC (μg/mL)a
(R)-12 (R)-13 RFP INH
1 M. tuberculosis H37Rv 2.31 2.31 0.07 0.24
2 M. tuberculosis H37Rv INHrb 2.91 1.52 0.03 >8
3 M. tuberculosis H37Rv RFPrc 2.91 1.51 >4 0.05
4 M. bovis BCG 3.00 2.95 - -
6 M. intracellulare ATCC15984 6.50 6.50 - -
7 M. smegmatis 6.50 6.50 - -
a

The agar plate dilution method was used.;

b

INH-resistant M. tuberculosis.; RFP-resistant M. tuberculosis.; RFP: rifampicin.; INH: isoniazid.