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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: J Med Chem. 2012 May 21;55(11):5413–5424. doi: 10.1021/jm300378k

Scheme 2. Syntheses of Dihalogenated DDB Analogues.

Scheme 2

Reagent and conditions: (a) Br2, CHCI3, 0°C, (b) CF3C02Ag, l2, (c) DIBAL, CH2CI2, (d) EDCI, DMAP, CH2CI2, CH3(CH2)2C02H for 32, and PhC02H for 33, (e) KOH, EtOH, reflux, (f) Ac20, reflux, (g) NaBH4, THF, MeOH