Table 1.
Numbers of unique peptides of transglutaminase 1, cornified envelope components and desmosome/corneodesmosome components identified by MS/MS-analysis in 2 or 3 independent samples derived from normal human skin, normal grafts, human LI skin and LI grafts.
| protein | MW | number of unique peptides
|
|||
|---|---|---|---|---|---|
| normal skin | normal graft | LI skin | LI graft | ||
| transglutaminase 1 | 90 kDa | 17,10 | 10,11 | 0,0 | 0,41,0 |
|
| |||||
| filaggrin | 435 kDa | 74,110 | 76,84 | 10,13 | 13,12,16 |
| keratinocyte proline-rich protein | 64 kDa | 35,39 | 35,34 | 70,59 | 51,55,53 |
| involucrin | 68 kDa | 16,3 | 3,11 | 15,5 | 14,5,10 |
| loricrin | 26 kDa | 2,2 | 0,2 | 29,24 | 16,18,22 |
| late cornified envelope protein 1C | 12 kDa | 2,2 | 0,0 | 5,4 | 9,8,8 |
| small proline-rich protein 1B | 10 kDa | 0,0 | 0,0 | 2,2 | 2,2,3 |
| desmoplakin | 332 kDa | 77,28 | 40,36 | 146,128 | 135,136,137 |
| junctional plakoglobin | 82 kDa | 30,14 | 13,19 | 51,38 | 55,56,53 |
| desmoglein 1 | 114 kDa | 25,19 | 14,24 | 53,43 | 45,39,44 |
| desmocollin 1 | 100 kDa | 7,0 | 0,10 | 16,17 | 12,8,10 |
| corneodesmosin | 52 kDa | 0,0 | 0,0 | 3,4 | 2,4,3 |
1
four unique TG1-peptides (GSGVNAAGDGTIR; GTNPSAWVGSVEILLSYLR; YDTPFIFAEVNSDK; NPLPVTLTNVVFR) detected in only one sample are identical to mouse TG1-peptides