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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Heart Rhythm. 2012 Feb 24;9(7):1090–1096. doi: 10.1016/j.hrthm.2012.02.023

Figure 1.

Figure 1

A large kindred segregating an SCN5A mutation (del1936C, Q646RfsX5) and two promoter variants (rs41310749 and rs41310239). Phenotypes (designated as mild or severe) and genotypes are indicated. Square symbols indicate males and round symbols indicate females. Slashed symbols indicate decreased individuals; Roman numerals indicate generations in the family. Arrhythmia phenotypes were classified as mild or severe. Individuals without cardiac symptoms were considered to have mild phenotype. Individuals with cardiac events, e.g. syncope, cardiac arrest or sudden cardiac death (SCD), were considered to have severe phenotype: SCD in a proband (IV-10, age 21 years), syncope in a brother (IV-11, age 21 years), and cardiac arrest in a cousin (IV-13, age 30 years).