Table 4. List of significantly differentially expressed transcripts between PD and PD.SHR4a (FDR<0.1, fold change >2). (a) Genes significantly overexpressed in PD.SHR4 vs PD (fold change >2); (b) genes significantly underexpressed in PD.SHR4 vs PD (fold change >2).
| Gene symbol | Gene name | Chr. | P-value | Fold change (PD vs PD.SHR4) |
|---|---|---|---|---|
| (a) | ||||
| Egr1 | Early growth response 1 | 18q | 1.28E−03 | 17.7 |
| Nat8 | N-acetyltransferase 8 (GCN5-related, putative) | 4q34 | 1.82E−03 | 11.5 |
| Abcg5 | ATP-binding cassette, sub-family G (WHITE), member 5 | 6q12 | 1.82E−04 | 11.2 |
| Igfbp2 | Insulin-like growth factor binding protein 2 | 9q33 | 1.04E−04 | 6.5 |
| Per3 | Period homolog 3 (Drosophila) | 5q36 | 1.01E−03 | 6.5 |
| Nr1i3 | nuclear receptor subfamily 1, group I, member 3 | 13q24 | 1.47E−03 | 5.7 |
| Por | P450 (cytochrome) oxidoreductase | 12q12 | 5.62E−04 | 4.8 |
| Per2 | Period homolog 2 (Drosophila) | 9q36 | 1.74E−03 | 4.6 |
| Aldh1a1 | Aldehyde dehydrogenase family 1, member A1 | 1q51 | 3.16E−03 | 4.6 |
| Gcnt2 | Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme | 17p12 | 3.49E−04 | 4.0 |
| Cyp2j2 | Cytochrome P450, family 2, subfamily J, polypeptide 2 | 5q33 | 8.50E−04 | 3.6 |
| Pdgfc | Platelet-derived growth factor, C polypeptide | 2q33 | 3.78E−03 | 2.8 |
| Abcb1a | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 4q12 | 1.08E−03 | 2.6 |
| Ces2b/Ces2c | carboxylesterase 2C | 1q55 | 7.83E−04 | 2.6 |
| Tmem8 | Rattus norvegicus transmembrane protein 48 | 10q12 | 1.85E−04 | 2.5 |
| Itpr1 | Inositol 1,4,5-triphosphate receptor, type 1 | 4q41 | 1.62E−03 | 2.4 |
| Abo | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 3p13 | 2.12E−03 | 2.4 |
| Abcd2 | ATP-binding cassette, sub-family D (ALD), member 2 | 7q35 | 9.16E−05 | 2.3 |
| C9orf95 | Chromosome 9 open reading frame 95 | 9 | 6.76E−04 | 2.3 |
| Herpud1 | Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 19p12 | 1.39E−03 | 2.1 |
| Pnpla7 | Patatin-like phospholipase domain containing 7 | 3p13 | 2.00E−03 | 2.1 |
| (b) | ||||
| Arntl | Aryl hydrocarbon receptor nuclear translocator-like | 1q34 | 1.72E−03 | −13.5 |
| Cd36 | Cd36/Fatty acid translocase | 4q11 | 3.08E−04 | −11.7 |
| Insig1 | insulin induced gene 1 | 4q11 | 1.87E−03 | −10.0 |
| Phf11 | PHD finger protein 11 | 15p12 | 1.76E−03 | −9.6 |
| Acpp | Acid phosphatase, prostate | 8q32 | 5.32E−04 | −7.0 |
| Apol3 | Apolipoprotein L, 3 | 7q34 | 2.37E−04 | −6.9 |
| Srd5a1 | Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 17p14 | 9.26E−04 | −6.7 |
| Slc34a2 | Solute carrier family 34 (sodium phosphate), member 2 | 14q11 | 7.86E−04 | −6.1 |
| Ltc4s | Leukotriene C4 synthase | 10q22 | 1.05E−03 | −5.7 |
| LOC360228 | WDNM1 homolog | 10q26 | 5.29E−04 | −5.3 |
| Nfil3 | Nuclear factor, interleukin 3 regulated | 17p14 | 3.00E−03 | −4.7 |
| Psmb8 | Proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) | 20p12 | 1.89E−03 | −3.1 |
| RGD1304580 | Similar to Hypothetical protein MGC38513 | 1q21 | 1.35E−03 | −2.9 |
| Cxadr | Coxsackie virus and adenovirus receptor | 11q11 | 4.83E−04 | −2.7 |
| Capg | capping protein (actin filament), gelsolin-like | 4q33 | 3.78E−03 | −2.7 |
| Oprs1 | Opioid receptor, sigma 1 | 5q22 | 1.98E−03 | −2.6 |
| Hamp | Hepcidin antimicrobial peptide | 1q21 | 2.43E−03 | −2.5 |
| Casp1 | Caspase 1 | 8q11 | 3.25E−03 | −2.5 |
| C6 | Complement component 6 | 2q16 | 1.01E−03 | −2.5 |
| Trim5 | Tripartite motif-containing 5 | 1q32 | 9.38E−04 | −2.3 |
| Tspo | Translocator protein | 7q34 | 3.56E−04 | −2.3 |
| Apobec1 | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | 4q42 | 3.07E−03 | −2.3 |
| Bst2 | Bone marrow stromal cell antigen 2 | 16p14 | 8.53E−04 | −2.2 |
| Pgrmc2 | Progesterone receptor membrane component 2 | 2q26 | 3.58E−03 | −2.2 |
| Vwa5a | Von Willebrand factor A domain containing 5A | 8q22 | 3.16E−03 | −2.1 |
| Gtf2ird1 | GTF2I repeat domain containing 1 | 12q12 | 4.54E−05 | −2.0 |
| Anxa3 | Annexin A3 | 14p22 | 1.32E−05 | −2.0 |
The P-value is adjusted for multiple comparisons.