Figure 2.

Omit electron density map for APV and mutated residues Ile32, Val47, and Ile82 in the two subunits of the PR_1M dimer. The map was contoured at 2.2σ level. Ile82 and 82′ in the S1/S1′ subsites interact with P1′ and P1 groups of the inhibitor. Ile32/32′ and Val47/47′ contribute to the S2/S2′ subsites and interact with the P2 and P2′ groups of APV. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]