Figure 5.

Structural comparison of DRV complexes with PR_1M, PR_1, and PR₂. The PR₁ structure is colored by atom type, PR_1M is shown in green bonds with the minor conformations of Ile32 and 32′ in cyan, and PR₂ is colored magenta. Only the major conformation of DRV is shown for PR₁-DRV. Hydrophobic interactions are indicated as dashed lines. CH…π interactions are indicated by dashed arrows. PR_1M is compared with PR₁ in the upper panels and with PR₂ in the lower panels. A: Residues 32 and 47 interactions with P2′ aniline of DRV; B: Residues 32′ and 47′ interactions with bis-THF at P2; and C: Residue 82 interactions with P1 of DRV. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]