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Morin Hydrate, but not Myricetin, Kaempferol, or Quercetin, inhibits amyloid formation by IAPP. TEM images shown are of the samples collected at 48 h after the initiation of amyloid formation. (A) IAPP alone, (B) IAPP:Myricetin = 1:1, (C) IAPP:Kaempferol = 1:1, (D) IAPP:Quercertin = 1:1, and (E) IAPP:Morin hydrate = 1:1. Experiments were conducted at 25°C, pH 7.4, 20 mM Tris-HCl, 32 μM IAPP, 0.25% DMSO (v/v). Inhibitors, when present, were at 32 μM. Scale bars represent 100 nm.
